SCIENTIFIC SECRETARIAT

Vincenza Calvaruso
Policlinico Palermo

Antonio Galante
ISMETT Palermo

WELCOME MESSAGE

Autoimmune liver diseases such as autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) pose ongoing clinical challenges due to their complexity, overlapping features, and limited treatment options. This educational event brings together national and international experts to share the latest insights into disease mechanisms, diagnostic tools, long-term management strategies, and emerging therapies.

The course opens with a state-of-the-art lecture on PSC, followed by sessions exploring new treatments, transplant timing, and the interplay between PSC and IBD. A dedicated session on miscellaneous but clinically relevant topics will cover CNI use, cholestatic pruritus, and innovations like organoids and pediatric liver transplantation.

The afternoon sessions focus on AIH, overlap syndromes, and PBC, emphasizing pathogenesis, noninvasive monitoring, and future therapeutic directions. Case-based discussions will promote interactive learning and clinical application.

Given the critical role of liver transplantation in advanced stages of autoimmune liver diseases, special attention will be dedicated to transplantation indications, outcomes, and post-transplant management in these patients.

By integrating scientific updates with real-world clinical experience, this course aims to support a more personalized and multidisciplinary approach to the care of patients with autoimmune liver diseases.

Endorsement by

PROGRAM

SEPTEMBER 18, 2025

14:30
Course presentation
V. Calvaruso, A. Galante

14:45
STATE OF THE ART LECTURE N.1
Autoimmune liver diseases in the landscape of ERN
P. Invernizzi / Introduction: M. Pinzani

1ST SESSION: AUTOIMMUNE HEPATITIS AND OVERLAP SYNDROMES
Chairs: V. Calvaruso, C. Cammà

15:15
Pathogenesis of Autoimmune Hepatitis
A. Lleo

15:35
Risk Stratification: Long-term Management After Immunosuppression
J. Drenth

15:55
PBC-AIH Overlap: Diagnostic Challenges and Advances in Therapy
A. Gerussi

16:15
Interactive Clinical Discussion: AIH
F. Colapietro

16:35
STATE OF THE ART LECTURE N.2
Adult liver transplantation in Sicily: a journey in the excellence
S. Gruttadauria / Introduction: G. Germani

2ND SESSION: PBC
Chairs: V. Calvaruso, TBD

17:05
Genes and immunity in PBC
U. Vespasiani Gentilucci

17:25
Role of Noninvasive Evaluation of Fibrosis and Portal Hypertension in PBC
M. Sebode

17:45
Innovations in therapies: toward new approaches
P.J. Trivedi

18:05
Interactive Clinical Discussion: PBC
G. Pennisi

SEPTEMBER 19, 2025

09:00
STATE OF THE ART LECTURE N. 3
PSC: where are we now and where are we going
T. Karlsen / Introduction: P. Invernizzi

3RD SESSION: PSC
Chairs: A. Galante, S. Petta

09:30
Emerging pharmacologic therapies for PSC
N. Cazzagon

09:50
Indications and timing for transplantation in PSC
E. Melum

10:10
PSC and IBD: one disease or two?
M. Carbone

10:30
Interactive Clinical Discussion PSC
L. Cristoferi

4TH SESSION: MISCELLANEOUS
Chairs: A. Galante, A. Moschetta

10:50
When the use of CNI is controversial: patients with autoimmune liver diseases and liver transplant patients
C. Celsa

11:10
Pruritus in Cholestasis
E. Culver

11:30
Organoid technology in the context of cholangiopathies
F. Sampaziotis

11:50
Genetic cholestasis: transition from adolescence to adulthood
L. D’Antiga

12:10
Liver transplantation in pediatric patients with autoimmune liver disease
G. Ranucci

12.30
Interactive Clinical Discussion CNI
M. Giacchetto

12:50
TAKE HOME MESSAGE
V. Calvaruso, A. Galantea

FACULTY

Vincenza Calvaruso, Palermo
Calogero Cammà, Palermo
Marco Carbone, Milan
Nora Cazzagon, Padua
Ciro Celsa, Palermo
Francesca Colapietro, Rozzano, MI
Laura Cristoferi, Milan
Emma Culver, Oxford, UK
Lorenzo D’Antiga
, Bergamo
Joost Drenth, Amsterdam, The Netherlands
Antonio Galante, Palermo
Giacomo Germani, Padua
Alessio Gerussi, Monza
Marco Giacchetto, Palermo

Salvatore Gruttadauria, Palermo
Pietro Invernizzi, Monza
Tom Karlsen, Oslo, Norway
Ana Lleo, Rozzano, MI
Espen Melum, Oslo, Norway
Antonio Moschetta, Bari
Grazia Pennisi, Palermo
Salvatore Petta, Palermo
Massimo Pinzani, Palermo
Giusy Ranucci, Palermo
Fotios Sampaziotis
, Cambridge, UK
Marcial Sebode, Hamburg, Germany
Palak Trivedi, Birmingham, UK
Umberto Vespasiani Gentilucci, Rome

INFORMATIONS

COURSE VENUE
Palazzo Steri - Sala Magna
Piazza Marina, 60 • 90133 Palermo • Italy

REGISTRATION
Registration fee (under 35): Free
Registration fee (over 35): Euro 200 VAT Included
Registration for the Congress is limited

C.M.E. - Continuing Medical Education
The event will be included by C.M.E. Provider Aristea Education (ID number: 500-454763) in its 2025 training plan within the framework of the National C.M.E. Program (Continuing Medical Education). The course is aimed at the following professional figures: Medical Doctor (Gastroenterology, Infectious Diseases, Internal Medicine, General Surgery, Pathology, Microbiology and Virology). The certification of C.M.E. credits is subject to participation in the entire training program and to a learning assessment test upon conclusion of the event. The certificate, indicating the number of credits awarded, will be available – once the above assessment has been completed – no earlier than 60 days after the conclusion of the event on the website: www.aristeaeducation.it, where further information about the National C.M.E. Program is also available. C.M.E. credits: 7.

TRAINING OBJECTIVE
Application of the principles and procedures of evidence -based practice (EBM - EBN - EBP) in daily practice.

PROVIDER E.C.M.

SEGRETERIA ORGANIZZATIVA